Article
Influenza virus interferon-inducing particle efficiency is reversed in avian and mammalian cells, and enhanced in cells co-infected with defective-interfering particles.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jun 2012
Ngunjiri John M, Lee Chang-Won, Ali Ahmed, Marcus Philip I
Abstract excerpt
Naturally selected variants of influenza virus encoding truncated NS1 proteins were tested in chickens as candidate live-attenuated influenza vaccines. Their effectiveness correlated with the amount of interferon (IFN) induced in chicken cells. Effective variants induced large amounts of IFN and contained subpopulations with high ratios of defective-interfering particles:IFN-inducing particles (DIP:IFP)....
Topics
- Animals
- Chickens
- Defective Viruses
- Influenza Vaccines
- Interferons
- Mammals
- Molecular Dynamics Simulation
- Orthomyxoviridae
- Phenotype