Article

LDOC1 loss reprograms histone ubiquitination and chromatin, driving tumor plasticity and poor prognosis in NSCLC

2025-08-06

Abstract excerpt

<title>Abstract</title> <p>Background Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, partly due to epigenetic dysregulation that drives tumor progression and metastasis. We previously showed that Leucine Zipper Downregulated in Cancer 1 (LDOC1) modulates the metastatic potential of NSCLC cells. Structural features of LDOC1 suggest potential interactions with nuclear histon...

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Literature Corpus work: 11800378-bb62-5d1c-9bfe-612c688a2b2a
DOI: 10.21203/rs.3.rs-7138921/v1

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