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Incorporating immunohistochemical markers into screening methods for BRCA1-mutated breast cancer.

Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jan 2020

Tuzimek Agnieszka, Fudalej Marta, Sobiborowicz Aleksandra, Budzik Michał, Badowska-Kozakiewicz Anna

Abstract excerpt

BRCA1-mutated breast cancer (BC) is responsible for approximately 25% of hereditary breast cancer cases. BRCA1 is a tumor suppressor protein regulating the cell cycle and DNA repair; therefore its dysfunctions play a significant role in carcinogenesis. BRCA1-mutated BC is associated with basal-like phenotype, lack of expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth...

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Identifiers

PMID: 33112117
DOI: 10.5114/pjp.2020.99793

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