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Article

Old and new concepts in histopathological characterization of familial breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 2011

Mangia A, Malfettone A, Simone G, Darvishian F

Abstract excerpt

BRCA1- and BRCA2-deficient cells display genomic instability due to impaired DNA repair and may subsequently be predisposed to malignant transformation. Cancers arising in BRCA1 gene mutation carriers differ substantially from sporadic breast cancers of age-matched controls in their histopathological appearance. BRCA1-related breast cancers have been morphologically associated with poorly differentiated and...

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Source

Identifiers

PMID: 21285147
DOI: 10.1093/annonc/mdq662

Genes

BRCA1
BRCA2
NHERF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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