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Article

BRCA mutation in breast cancer patients: Prognostic impact and implications on clinical management.

The breast journal - 1 Nov 2018

Loi Mauro, Desideri Isacco, Olmetto Emanuela, Francolini Giulio, Greto Daniela, Bonomo Pierluigi, Simontacchi Gabriele, Di Brina Lucia, Meattini Icro, Livi Lorenzo

Abstract excerpt

BRCA1/2 mutations are involved in breast cancer (BC) susceptibility but their influence on outcome is unclear. We reviewed BC patients tested for BRCA to determine biological features and influence on outcome. BRCA-1 was correlated to younger age (P = 0.035), nodal involvement (P = 0.030), higher tumor grade (P = 0.0022) and Ki-67 (P = 0.014), ER/PgR negative status (P = 0.00042 and 0.0091, respectively), and use...

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Identifiers

PMID: 30066348
DOI: 10.1111/tbj.13100

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BRCA1

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