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Clinical outcome of breast cancer in carriers of BRCA1 and BRCA2 mutations according to molecular subtypes

27 Apr 2020

Abstract excerpt

BRCA1/BRCA2 genes play a central role in DNA repair and their mutations increase sensitivity to DNA-damaging agents. There are conflicting data regarding the prognostic value of BRCA germline mutations in breast cancer (BC) patients. We collected clinical, pathological and genetic data of a cohort 925 BC patients preselected for genetic screening and treated with neoadjuvant or adjuvant chemotherapy, of whom 266...

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PMID: 32341426
DOI: 10.1038/s41598-020-63759-1

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