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Article

Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency.

Scientific reports - 27 Oct 2020

Cacciante Francesco, Gennaro Mariangela, Sagona Giulia, Mazziotti Raffaele, Lupori Leonardo, Cerri Elisa, Putignano Elena, Butt Mark, Do Minh-Ha T, McKew John C, Alessandrì Maria Grazia, Battini Roberta, Cioni Giovanni, Pizzorusso Tommaso, Baroncelli Laura

Abstract excerpt

Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy. There is currently no cure for this disorder. Here, we employed novel biomarkers for monitoring brain function, together with well-established behavioral readouts for CTD mice, to longitudinally study the therapeutic efficacy of cyclocreatine (cCr) at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33110151
DOI: 10.1038/s41598-020-75436-4
PMCID: PMC7591530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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