Article

Connectomic and behavioral alterations in creatine transporter deficiency are partially normalized by gene therapy

2024-01-12

Abstract excerpt

Creatine Transporter Deficiency (CTD) is an X-linked disorder due to the loss of SLC6A8 gene and presenting with low brain creatine, intellectual disability, autistic-like behavior and seizures. No treatments are available yet for CTD, and little is known about the brain circuit alterations underlying its pathological endophenotypes. Here, we tracked brain network and behavioral dysfunction in a murine model of C...

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Literature Corpus work: a4f9d4f8-1d1c-5a37-b201-e25fed9dd6d7
DOI: 10.1101/2024.01.12.575377

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