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Article

Impact of extracellular matrix stiffness on genomic heterogeneity in MYCN-amplified neuroblastoma cell line.

Journal of experimental & clinical cancer research : CR - 28 Oct 2020

López-Carrasco Amparo, Martín-Vañó Susana, Burgos-Panadero Rebeca, Monferrer Ezequiel, Berbegall Ana P, Fernández-Blanco Beatriz, Navarro Samuel, Noguera Rosa

Abstract excerpt

BACKGROUND: Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to a stiff matrix, is present in a particularly increased quantity and specific distribution in high-risk neuroblastoma. Furthermore, as cells can sense and transform the proprieties of the...

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Share to Extracellular Matrix
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Mechanotransduction, Cellular

Share to N-Myc Proto-Oncogene Protein

Share to Neuroblastoma

Share to Tumor Cells, Cultured

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Source

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Identifiers

PMID: 33109237
DOI: 10.1186/s13046-020-01729-1
PMCID: PMC7592549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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