Article

The Extracellular Matrix Regulates Invasion in Fusion-Negative Rhabdomyosarcoma via YAP-PIEZO1 Signaling Axis

2026-01-05

Abstract excerpt

<h4>Background</h4> Fusion-negative rhabdomyosarcoma (FNRMS) represents the most prevalent subtype of rhabdomyosarcoma, the most common pediatric soft tissue sarcoma. Although its invasion is a leading cause of recurrence and poor prognosis, its underlying mechanism remains unclear. We investigated how extracellular matrix (ECM) density regulates FNRMS progression via mechano-transduction. <h4>Methods</h4> We us...

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Literature Corpus work: d89d5bc1-3fb5-5631-81c6-50ca791d1820
DOI: 10.64898/2026.01.05.697722

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