Article

Impact of extracellular matrix stiffness on genomic heterogeneity in MYCN-amplified neuroblastoma cell line

2020-10-06

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to a stiff matrix, is present in a particularly increased quantity and specific distribution in high-risk neuroblastoma. Furthermore, as cells can sense and tr...

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Literature Corpus work: ad94490c-7492-5a46-b864-6c980cad2f7e
DOI: 10.21203/rs.3.rs-59368/v2

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