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Article

Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.

Nature communications - 14 Apr 2020

Xu Zhi-Xiang, Kim Gyu Hyun, Tan Ji-Wei, Riso Anna E, Sun Ye, Xu Ethan Y, Liao Guey-Ying, Xu Haifei, Lee Sang-Hoon, Do Na-Young, Lee Chan Hee, Clipperton-Allen Amy E, Kwon Soonwook, Page Damon T, Lee Kea Joo, Xu Baoji

Abstract excerpt

Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction and communication deficits and repetitive behaviors. However, the cells that cause ASD through elevated protein synthesis resulting from these mutations remain unknown. Here we employ conditional overexpression of translation initiation factor eIF4E to...

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Identifiers

PMID: 32286273
DOI: 10.1038/s41467-020-15530-3
PMCID: PMC7156673

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