Article
Priming of microglia in a DNA-repair deficient model of accelerated aging.
Neurobiology of aging - 1 Sept 2014
Raj Divya D A, Jaarsma Dick, Holtman Inge R, Olah Marta, Ferreira Filipa M, Schaafsma Wandert, Brouwer Nieske, Meijer Michel M, de Waard Monique C, van der Pluijm Ingrid, Brandt Renata, Kreft Karim L, Laman Jon D, de Haan Gerald, Biber Knut P H, Hoeijmakers Jan H J, Eggen Bart J L, Boddeke Hendrikus W G M
Abstract excerpt
Aging is associated with reduced function, degenerative changes, and increased neuroinflammation of the central nervous system (CNS). Increasing evidence suggests that changes in microglia cells contribute to the age-related deterioration of the CNS. The most prominent age-related change of microglia is enhanced sensitivity to inflammatory stimuli, referred to as priming. It is unclear if priming is due to...
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