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Article

mTORC1-S6K activation by endotoxin contributes to cytokine up-regulation and early lethality in animals.

PloS one - 21 Dec 2010

Lee Po-Shun, Wilhelmson Anna S K, Hubner Anton P, Reynolds Samuel B, Gallacchi Dana A, Chiou Terry T, Kwiatkowski David J

Abstract excerpt

BACKGROUND: mTORC1 (mammalian target of rapamycin complex 1) activation has been demonstrated in response to endotoxin challenge, but the mechanism and significance are unclear. We investigated the effect of mTORC1 suppression in an animal model of endotoxemia and in a cellular model of endotoxin signaling. METHODOLOGY/PRINCIPAL FINDINGS: Mice were treated with the mTORC1 inhibitor rapamycin or vehicle prior to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21200439
DOI: 10.1371/journal.pone.0014399
PMCID: PMC3006197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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