Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.

doi:10.1371/journal.pone.0087057

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Article

Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.

PloS one - 1 Jan 2014

Hua Rui-Xi, Li He-Ping, Liang Yan-Bing, Zhu Jin-Hong, Zhang Bing, Ye Sheng, Dai Qiang-Sheng, Xiong Shi-Qiu, Gu Yong, Sun Xiang-Zhou

Abstract excerpt

BACKGROUND: Poly (ADP-ribose) polymerase-1 (PARP-1) plays critical roles in the detection and repair of damaged DNA, as well as cell proliferation and death. Numerous studies have examined the associations between PARP1 Val762Ala (rs1136410 T>C) polymorphism and cancer susceptibility; nevertheless, the findings from different research groups remain controversial. METHODS: We searched literatures from MEDLINE,...

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PMID: 24489833
DOI: 10.1371/journal.pone.0087057
PMCID: PMC3904982

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PARP1

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