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Article

Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008

Wiktor-Brown Dominika M, Kwon Hyuk-Sang, Nam Yoon Sung, So Peter T C, Engelward Bevin P

Abstract excerpt

The clonal expansion of mutant cells is hypothesized to be an important first step in cancer formation. To understand the earliest stages of tumorigenesis, a method to identify and analyze clonal expansion is needed. We have previously described transgenic Fluorescent Yellow Direct Repeat (FYDR) mice in which cells that have undergone sequence rearrangements (via homologous recombination events) express a...

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Source

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Identifiers

PMID: 18647827
DOI: 10.1073/pnas.0804346105
PMCID: PMC2492490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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