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Article

USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L–SMAD pathway

26 Oct 2020

Abstract excerpt

Significance Protein homeostasis is fundamental to the functioning of all living cells. Perturbation of the homeostasis, or proteotoxicity, plays an important role in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative diseases. To guard against proteotoxicity, cells have evolved sophisticated quality-control mechanisms that make adaptations including enhanced turnover of misfolded...

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PMID: 33106424
DOI: 10.1073/pnas.2014349117

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