Article
The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting.
Biochemical Society transactions - 1 Apr 2003
Ciechanover A
Abstract excerpt
Until the early 1980s, protein degradation was a neglected research area, and scientists were mostly busy deciphering the genetic code and its translation to the proteome. Destruction of cellular proteins was thought to be a scavenger, non-specific and dead-end process. Although it was known that proteins do turn over, the large extent and high specificity of the process, whereby distinct proteins have half-lives...
Topics
- Disease
- Drug Therapy
- Humans
- Mutation
- Peptide Hydrolases
- Ubiquitin