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Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways

20 May 2021

Abstract excerpt

Coordinated regulation of stress response pathways is crucial for cellular homeostasis. However, crosstalk between the different stress pathways and the physiological significance of this crosstalk remain poorly understood. In this study, using the model organism C. elegans, we discovered that suppression of the transcription factor LET-607/CREBH, a regulator of cellular defense and proteostatic responses,...

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PMID: 34014977
DOI: 10.1371/journal.pgen.1009573

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