Article
Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening.
The EMBO journal - 1 Apr 2003
Kurz C Léopold, Chauvet Sophie, Andrès Emmanuel, Aurouze Marianne, Vallet Isabelle, Michel Gérard P F, Uh Mitch, Celli Jean, Filloux Alain, De Bentzmann Sophie, Steinmetz Ivo, Hoffmann Jules A, Finlay B Brett, Gorvel Jean-Pierre, Ferrandon Dominique, Ewbank Jonathan J
Abstract excerpt
The human opportunistic pathogen Serratia marcescens is a bacterium with a broad host range, and represents a growing problem for public health. Serratia marcescens kills Caenorhabditis elegans after colonizing the nematode's intestine. We used C.elegans to screen a bank of transposon-induced S.marcescens mutants and isolated 23 clones with an attenuated virulence. Nine of the selected bacterial clones also...
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