Article
Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.
PloS one - 1 Jan 2021
Sarnowski Chloé, Chen Han, Biggs Mary L, Wassertheil-Smoller Sylvia, Bressler Jan, Irvin Marguerite R, Ryan Kathleen A, Karasik David, Arnett Donna K, Cupples L Adrienne, Fardo David W, Gogarten Stephanie M, Heavner Benjamin D, Jain Deepti, Kang Hyun Min, Kooperberg Charles, Mainous Arch G, Mitchell Braxton D, Morrison Alanna C, O'Connell Jeffrey R, Psaty Bruce M, Rice Kenneth, Smith Albert V, Vasan Ramachandran S, Windham B Gwen, Kiel Douglas P, Murabito Joanne M, Lunetta Kathryn L
Abstract excerpt
Handgrip strength is a widely used measure of muscle strength and a predictor of a range of morbidities including cardiovascular diseases and all-cause mortality. Previous genome-wide association studies of handgrip strength have focused on common variants primarily in persons of European descent. We aimed to identify rare and ancestry-specific genetic variants associated with handgrip strength by conducting...
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