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Article

Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations.

Nature communications - 6 Feb 2026

Hawkes Gareth, Wright Harrison I W, Beaumont Robin N, Chundru Kartik, Hanson Aimee, Jackson Leigh, Murray Anna, Patel Kashyap, Frayling Timothy M, Wright Caroline F, Wood Andrew R, Weedon Michael N

Abstract excerpt

GWAS have generally focused on common variants from genotyping arrays or rare protein-coding variants from exome sequencing. Here, we use whole-genome sequencing data to evaluate the contribution to and architecture of rare non-coding variants for three commonly studied anthropometric traits: height, BMI and waist-hip ratio adjusted for BMI. Analysing 447,461 individuals in the UK Biobank for discovery and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41651857
DOI: 10.1038/s41467-026-69208-3
PMCID: PMC12987921

Genes

FGF18
IGF2BP2
UBR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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