Article
Identification of Genomic Predictors of Muscle Fiber Size.
Cells - 18 Jul 2024
Guilherme João Paulo L F, Semenova Ekaterina A, Kikuchi Naoki, Homma Hiroki, Kozuma Ayumu, Saito Mika, Zempo Hirofumi, Matsumoto Shingo, Kobatake Naoyuki, Nakazato Koichi, Okamoto Takanobu, John George, Yusupov Rinat A, Larin Andrey K, Kulemin Nikolay A, Gazizov Ilnaz M, Generozov Edward V, Ahmetov Ildus I
Abstract excerpt
The greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of sarcopenia. Muscle fiber size is a polygenic trait influenced by both environmental and genetic factors. However, the genetic variants underlying inter-individual differences in muscle fiber size remain largely unknown. The aim of our study...
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