Article
Genome-wide association study identified copy number variants important for appendicular lean mass.
PloS one - 1 Jan 2014
Ran Shu, Liu Yong-Jun, Zhang Lei, Pei Yufang, Yang Tie-Lin, Hai Rong, Han Ying-Ying, Lin Yong, Tian Qing, Deng Hong-Wen
Abstract excerpt
Skeletal muscle is a major component of the human body. Age-related loss of muscle mass and function contributes to some public health problems such as sarcopenia and osteoporosis. Skeletal muscle, mainly composed of appendicular lean mass (ALM), is a heritable trait. Copy number variation (CNV) is a common type of human genome variant which may play an important role in the etiology of many human diseases. In...
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