Article
Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches.
Scientific reports - 23 Oct 2020
Güler Rezan, Svedmark Siri Flemming, Abouzayed Ayman, Orlova Anna, Löfblom John
Abstract excerpt
The family of vascular endothelial growth factor (VEGF) ligands and their interactions with VEGF receptors (VEGFRs) play important roles in both pathological and physiological angiogenesis. Hence, agonistic and antagonistic ligands targeting this signaling pathway have potential for both studies on fundamental biology and for development of therapies and diagnostics. Here, we engineer VEGFR2-binding affibody...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.