Klotho, PTSD, and advanced epigenetic age in cortical tissue.

doi:10.1038/s41386-020-00884-5

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Article

Klotho, PTSD, and advanced epigenetic age in cortical tissue.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2021

Wolf Erika J, Chen Ci-Di, Zhao Xiang, Zhou Zhenwei, Morrison Filomene G, Daskalakis Nikolaos P, Stone Annjanette, Schichman Steven, Grenier Jaclyn Garza, Fein-Schaffer Dana, Huber Bertrand R, Abraham Carmela R, Miller Mark W, Logue Mark W

Abstract excerpt

This study examined the klotho (KL) longevity gene polymorphism rs9315202 and psychopathology, including posttraumatic stress disorder (PTSD), depression, and alcohol-use disorders, in association with advanced epigenetic age in three postmortem cortical tissue regions: dorsolateral and ventromedial prefrontal cortices and motor cortex. Using data from the VA National PTSD Brain Bank (n = 117), we found that...

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Identifiers

PMID: 33096543
DOI: 10.1038/s41386-020-00884-5
PMCID: PMC8027437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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