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Article

PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.

Psychoneuroendocrinology - 1 Jul 2020

Wolf Erika J, Logue Mark W, Zhao Xiang, Daskalakis Nikolaos P, Morrison Filomene G, Escarfulleri Shaline, Stone Annjanette, Schichman Steven A, McGlinchey Regina E, Milberg William P, Chen Cidi, Abraham Carmela R, Miller Mark W

Abstract excerpt

BACKGROUND: Longevity gene klotho (KL) is associated with age-related phenotypes including lifespan, cardiometabolic disorders, cognition, and brain morphology, in part, by conferring protection against inflammation. We hypothesized that the KL/inflammation association might be altered in the presence of psychiatric stress and operate via epigenetic pathways. We examined KL polymorphisms, and their interaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32438247
DOI: 10.1016/j.psyneuen.2020.104656
PMCID: PMC7293549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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