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Article

eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA

23 Oct 2020

Abstract excerpt

Emerging advances in cancer therapy have transformed the landscape towards cancer immunotherapy regimens. Recent discoveries have resulted in the development of clinical immune checkpoint inhibitors that are 'game-changers' for cancer immunotherapy. Here we show that eEF2K, an atypical protein kinase that negatively modulates the elongation stage of protein synthesis, promotes the synthesis of PD-L1, an immune...

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PMID: 33094805
DOI: 10.1042/bcj20200697

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