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The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies

25 Apr 2024

Abstract excerpt

Eukaryotic elongation factor 1A (eEF1A) is among the most abundant proteins in eukaryotic cells. Evolutionarily conserved across species, eEF1A is in charge of translation elongation for protein biosynthesis as well as a plethora of non-translational moonlighting functions for cellular homeostasis. In malignant cells, however, eEF1A becomes a pleiotropic driver of cancer progression via a broad diversity of...

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PMID: 38677532
DOI: 10.1016/j.phrs.2024.107195

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