Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.

doi:10.1158/1078-0432.CCR-19-1800

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Article

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2020

Smith Jenny L, Ries Rhonda E, Hylkema Tiffany, Alonzo Todd A, Gerbing Robert B, Santaguida Marianne T, Eidenschink Brodersen Lisa, Pardo Laura, Cummings Carrie L, Loeb Keith R, Le Quy, Imren Suzan, Leonti Amanda R, Gamis Alan S, Aplenc Richard, Kolb E Anders, Farrar Jason E, Triche Timothy J, Nguyen Cu, Meerzaman Daoud, Loken Michael R, Oehler Vivian G, Bolouri Hamid, Meshinchi Soheil

Abstract excerpt

PURPOSE: A cryptic inv(16)(p13.3q24.3) encoding the CBFA2T3-GLIS2 fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our understanding of the pathogenesis of this fusion through transcriptome profiling. EXPERIMENTAL DESIGN: Available RNA from children and young adults with de novo acute myeloid leukemia (AML; N = 1,049) underwent transcriptome sequencing...

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Identifiers

PMID: 31719049
DOI: 10.1158/1078-0432.CCR-19-1800
PMCID: PMC7002196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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