Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.

doi:10.1016/j.immuni.2021.03.001

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Article

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.

Immunity - 13 Apr 2021

Ehx Grégory, Larouche Jean-David, Durette Chantal, Laverdure Jean-Philippe, Hesnard Leslie, Vincent Krystel, Hardy Marie-Pierre, Thériault Catherine, Rulleau Caroline, Lanoix Joël, Bonneil Eric, Feghaly Albert, Apavaloaei Anca, Noronha Nandita, Laumont Céline M, Delisle Jean-Sébastien, Vago Luca, Hébert Josée, Sauvageau Guy, Lemieux Sébastien, Thibault Pierre, Perreault Claude

Abstract excerpt

Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Using an original proteogenomic approach, we analyzed the major histocompatibility complex class I (MHC class I)-associated immunopeptidome of 19 primary AML samples and identified 58 tumor-specific antigens (TSAs). These TSAs bore no mutations and derived mainly (86%) from...

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PMID: 33740418
DOI: 10.1016/j.immuni.2021.03.001

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