Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.

Nature medicine - 1 Apr 2022

Khabirova Eleonora, Jardine Laura, Coorens Tim H H, Webb Simone, Treger Taryn D, Engelbert Justin, Porter Tarryn, Prigmore Elena, Collord Grace, Piapi Alice, Teichmann Sarah A, Inglott Sarah, Williams Owen, Heidenreich Olaf, Young Matthew D, Straathof Karin, Bomken Simon, Bartram Jack, Haniffa Muzlifah, Behjati Sam

Abstract excerpt

KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia (B-ALL) using bulk messenger RNA (mRNA) meta-analysis and examination of single lymphoblast transcriptomes against a developing bone marrow reference. KMT2A-rearranged infant B-ALL was uniquely dominated by an early...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Infant

Share to Mutation

Share to Myeloid-Lymphoid Leukemia Protein

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 35288693
DOI: 10.1038/s41591-022-01720-7
PMCID: PMC9018413

Genes

KMT2A
NUTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.PMID 35288693Read ↗

Single cell mRNA signals reveal a distinct developmental state of <i>KMT2A</i> -rearranged infant B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of <i>KMT2A</i> -rearranged leukemiaSemantic proximity Read ↗

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemiaSemantic proximity Read ↗

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A -rearranged leukemiaSemantic proximity Read ↗

KMT2A rearranged acute lymphoblastic leukaemia: Unravelling the genomic complexity and heterogeneity of this high-risk disease.Semantic proximity Read ↗

Updates in the biology and therapy for infant acute lymphoblastic leukemiaSemantic proximity Read ↗

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.Semantic proximity Read ↗

Cryptic recurrent ACIN1‐NUTM1 fusions in non‐KMT2A‐rearranged infant acute lymphoblastic leukemiaSemantic proximity Read ↗

Updates in KMT2A Gene Rearrangement in Pediatric Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groupsSemantic proximity Read ↗

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysisSemantic proximity Read ↗

Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.