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Rational Combinatorial Targeting by Adapter CAR T Cells (AdCAR-T) Prevents Antigen Escape in Acute Myeloid Leukemia (AML)

2023-11-29

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<title>Abstract</title> <p>Targeting AML by chimeric antigen receptor T cells (CAR-T) has been challenging due to the promiscuous expression of AML-associated antigens on healthy hematopoietic stem and progenitor cells as well as a high degree of inter- and intratumoral heterogeneity. Consequently, we did not yet see dramatic clinical successes, as in B-phenotypic malignancies treated with CD19- or BCMA-directed...

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Literature Corpus work
e9ff6ed6-accb-5673-a4c6-25fb11527fa0
DOI
10.21203/rs.3.rs-3659780/v1
Open publication

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Rational Combinatorial Targeting by Adapter CAR T Cells (AdCAR-T) Prevents Antigen Escape in Acute Myeloid Leukemia (AML)DOI 10.21203/rs.3.rs-3659780/v1
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