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Article

Gelator length precisely tunes supramolecular hydrogel stiffness and neuronal phenotype in 3D culture.

ACS biomaterials science & engineering - 10 Feb 2020

Godbe Jacqueline M, Freeman Ronit, Burbulla Lena F, Lewis Jacob, Krainc Dimitri, Stupp Samuel I

Abstract excerpt

The brain is one of the softest tissues in the body with storage moduli (G') that range from hundreds to thousands of pascals (Pa) depending upon the anatomic region. Furthermore, pathological processes such as injury, aging and disease can cause subtle changes in the mechanical properties throughout the central nervous system. However, these changes in mechanical properties lie within an extremely narrow range...

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PMID: 33094153
DOI: 10.1021/acsbiomaterials.9b01585
PMCID: PMC7575210

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