Article
Tripeptide-based amyloid hydrogels: phenylalanine mutation outcomes on self-assembly, hydrogelation and their cytotoxicity assays.
Journal of materials chemistry. B - 16 Sept 2026
Bera Abhinandan, Sivaravi Maheswari, Ghosal Souvik, Bag Sagar, Bhowmik Sudipta, Meena Sunil Kumar, Das Bikram, Ganguly Anasuya, Roy Subhasish
Abstract excerpt
A tripeptide segment Leu-Val-Phe (Aβ17-19) has been judiciously selected from the core β-amyloid (Aβ1-42) peptide sequence. Seven tripeptides with the general sequence Boc-Leu-Val-X-COOH (Boc-LVX-OH), where X = L-phenylalanine, L-4-nitro-phenylalanine, L-tyrosine, L-3-nitro-tyrosine, L-tryptophan, L-valine, and γ-amino butyric acid for AP1 to AP7, respectively, have been synthesized to study their aggregation...
Read the complete abstract on PubMedTopics
- Hydrogels
- Phenylalanine
- Amyloid beta-Peptides
- Animals
- Cell Survival
- Oligopeptides