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A Self-Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer.

Advanced healthcare materials - 1 Jul 2024

Liu Ying, Okesola Babatunde O, Osuna de la Peña David, Li Weiqi, Lin Meng-Lay, Trabulo Sara, Tatari Marianthi, Lawlor Rita T, Scarpa Aldo, Wang Wen, Knight Martin, Loessner Daniela, Heeschen Christopher, Mata Alvaro, Pearce Oliver M T

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense and stiff extracellular matrix (ECM) associated with tumor progression and therapy resistance. To further the understanding of how stiffening of the tumor microenvironment (TME) contributes to aggressiveness, a three-dimensional (3D) self-assembling hydrogel disease model is developed based on peptide amphiphiles (PAs, PA-E3Y) designed to tailor...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 38471128
DOI: 10.1002/adhm.202301941
PMCID: PMC11468796

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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