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Article

Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype.

Acta biomaterialia - 15 Jul 2024

Mathes Tess Grett, Monirizad Mahsa, Ermis Menekse, de Barros Natan Roberto, Rodriguez Marco, Kraatz Heinz-Bernhard, Jucaud Vadim, Khademhosseini Ali, Falcone Natashya

Abstract excerpt

Self-assembling peptide-based hydrogels have become a highly attractive scaffold for three-dimensional (3D) in vitro disease modeling as they provide a way to create tunable matrices that can resemble the extracellular matrix (ECM) of various microenvironments. Alzheimer's disease (AD) is an exceptionally complex neurodegenerative condition; however, our understanding has advanced due to the transition from...

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Identifiers

PMID: 38801867
DOI: 10.1016/j.actbio.2024.05.020
PMCID: PMC11239292

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