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Article

hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.

Stem cell reports - 8 May 2018

Adil Maroof M, Gaj Thomas, Rao Antara T, Kulkarni Rishikesh U, Fuentes Christina M, Ramadoss Gokul N, Ekman Freja K, Miller Evan W, Schaffer David V

Abstract excerpt

Huntington disease (HD) is an inherited, progressive neurological disorder characterized by degenerating striatal medium spiny neurons (MSNs). One promising approach for treating HD is cell replacement therapy, where lost cells are replaced by MSN progenitors derived from human pluripotent stem cells (hPSCs). While there has been remarkable progress in generating hPSC-derived MSNs, current production methods rely...

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PMID: 29628395
DOI: 10.1016/j.stemcr.2018.03.007
PMCID: PMC5995679

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