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Article

HLA polymorphism in neuroimmune diseases: linking antigen presentation to neuroinflammatory programs.

Frontiers in immunology - 1 Jan 2026

Liu Shuo, Yang Siwen, Hu Jing, Bai Tao, Li Jian-Ping

Abstract excerpt

Human leukocyte antigen (HLA) polymorphism shapes antigen presentation and susceptibility to immune-mediated disease. In neuroimmune disorders, a central question is how HLA-dependent antigen visibility becomes disease-specific immunity and tissue injury. In this Review, we integrate genetic, molecular, cellular, and clinical evidence across multiple sclerosis (MS), neuromyelitis optica spectrum disorder,...

Read the complete abstract on PubMed

Topics

Humans
Antigen Presentation
Polymorphism, Genetic
HLA Antigens
Genetic Predisposition to Disease
Neuroinflammatory Diseases

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Animals

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Identifiers

PMID: 42682948
DOI: 10.3389/fimmu.2026.1863697
PMCID: PMC13531444

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