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Article

Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored.

Trends in molecular medicine - 1 Apr 2016

Li Stephen K H, Martin Alberto

Abstract excerpt

Colorectal cancer (CRC) remains one of the most prevalent cancers worldwide. In sporadic CRC, mutations frequently occur in the DNA mismatch repair (MMR) pathway. In addition, germline MMR mutations have been linked to Lynch syndrome, the most common form of hereditary CRC. Although genetic mutations, diet, inflammation, and the gut microbiota can influence CRC, it is unclear how MMR deficiency relates to these...

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PMID: 26970951
DOI: 10.1016/j.molmed.2016.02.003

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