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Article

News from the protein mutability landscape.

Journal of molecular biology - 1 Nov 2013

Hecht Maximilian, Bromberg Yana, Rost Burkhard

Abstract excerpt

Some mutations of protein residues matter more than others, and these are often conserved evolutionarily. The explosion of deep sequencing and genotyping increasingly requires the distinction between effect and neutral variants. The simplest approach predicts all mutations of conserved residues to have an effect; however, this works poorly, at best. Many computational tools that are optimized to predict the...

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Identifiers

PMID: 23896297
DOI: 10.1016/j.jmb.2013.07.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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