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Article

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

27 Jan 2017

Abstract excerpt

Abstract Keratin 16 (K16) is a cytoskeletal scaffolding protein highly expressed at pressure-bearing sites of the mammalian footpad. It can be induced in hyperproliferative states such as wound healing, inflammation and cancer. Here we show that the inactive rhomboid protease RHBDF2 (iRHOM2) regulates thickening of the footpad epidermis through its interaction with K16. K16 expression is absent in the thinned...

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PMID: 28128203
DOI: 10.1038/ncomms14174

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