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RIPK4 regulates cell–cell adhesion in epidermal development and homeostasis

24 Feb 2022

Abstract excerpt

Epidermal development and maintenance are finely regulated events requiring a strict balance between proliferation and differentiation. Alterations in these processes give rise to human disorders such as cancer or syndromes with skin and annexes defects, known as ectodermal dysplasias (EDs). Here, we studied the functional effects of two novel receptor-interacting protein kinase 4 (RIPK4) missense mutations...

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PMID: 35220430
DOI: 10.1093/hmg/ddac046

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