Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

5 Mar 2018

Abstract excerpt

Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis. Inherited gain-of-function mutations in RHBDF2 (encoding iRHOM2) are associated with a hyperproliferative palmoplantar keratoderma and squamous oesophageal cancer syndrome (termed TOC). In contrast, genetic ablation of rhbdf2 in mice leads to a thinning of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Fibroblast Growth Factor Research
Share to Kruppel-like factors research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29523849
DOI: 10.1038/s41467-018-03470-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress responsePMID 29523849Read ↗

iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility.Semantic proximity Read ↗

Master regulatory role of p63 in epidermal development and disease.Semantic proximity Read ↗

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiationSemantic proximity Read ↗

Complex multipathways alterations and oxidative stress are associated with Hailey-Hailey disease.Semantic proximity Read ↗

Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.Semantic proximity Read ↗

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16Semantic proximity Read ↗

Molecular and Cellular Function of p63 in Skin Development and Genetic DiseasesSemantic proximity Read ↗

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasiaSemantic proximity Read ↗

Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activitySemantic proximity Read ↗

Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.Semantic proximity Read ↗

A PERK-FOXO1 AXIS LINKS DNA DAMAGE TO FIBROBLAST SURVIVAL IN DIFFUSE CUTANEOUS SYSTEMIC SCLEROSISSemantic proximity Read ↗

The KEAP1/NRF2 Signaling Pathway in KeratinizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.