Article

Keratin 16 spatially inhibits type I interferon responses in stressed and diseased skin

2024-12-28

Abstract excerpt

The stress-induced keratin 16 is broadly used as a biomarker in inflammatory skin disorders while pathogenic variants in KRT16 cause pachyonychia congenita (PC), a condition in which differentiation and homeostasis are disrupted in palmoplantar epidermis and epithelial appendages. How K16 impacts these disorders at a molecular level is poorly understood. Here we report that K16 spatially restricts type I interfer...

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Literature Corpus work: da1d048c-eff7-5562-a334-6e8eca045218
DOI: 10.1101/2024.12.27.630544

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