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Article

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling.

Developmental cell - 7 Dec 2020

Bustos Francisco, Segarra-Fas Anna, Nardocci Gino, Cassidy Andrew, Antico Odetta, Davidson Lindsay, Brandenburg Lennart, Macartney Thomas J, Toth Rachel, Hastie C James, Moran Jennifer, Gourlay Robert, Varghese Joby, Soares Renata F, Montecino Martin, Findlay Greg M

Abstract excerpt

Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-rich splicing factor (SRSF) protein kinase (SRPK), which is implicated in splicing regulation, is one such conserved eukaryotic kinase. Surprisingly, we show that SRPK has acquired the capacity to control a neurodevelopmental ubiquitin...

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Identifiers

PMID: 33080171
DOI: 10.1016/j.devcel.2020.09.025
PMCID: PMC7725506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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