Article
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Nature communications - 28 Feb 2020
Dian Cyril, Pérez-Dorado Inmaculada, Rivière Frédéric, Asensio Thomas, Legrand Pierre, Ritzefeld Markus, Shen Mengjie, Cota Ernesto, Meinnel Thierry, Tate Edward W, Giglione Carmela
Abstract excerpt
The promising drug target N-myristoyltransferase (NMT) catalyses an essential protein modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high-resolution human NMT1 structures co-crystallised with reactive cognate lipid and peptide substrates, revealing high-resolution snapshots of the entire catalytic mechanism from the initial to final reaction states. Structural...
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