Article
Landscape and function of multiple mutations within individual oncogenes.
Nature - 1 Jun 2020
Saito Yuki, Koya Junji, Araki Mitsugu, Kogure Yasunori, Shingaki Sumito, Tabata Mariko, McClure Marni B, Yoshifuji Kota, Matsumoto Shigeyuki, Isaka Yuta, Tanaka Hiroko, Kanai Takanori, Miyano Satoru, Shiraishi Yuichi, Okuno Yasushi, Kataoka Keisuke
Abstract excerpt
Sporadic reports have described cancer cases in which multiple driver mutations (MMs) occur in the same oncogene1,2. However, the overall landscape and relevance of MMs remain elusive. Here we carried out a pan-cancer analysis of 60,954 cancer samples, and identified 14 pan-cancer and 6 cancer-type-specific oncogenes in which MMs occur more frequently than expected: 9% of samples with at least one mutation in...
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