Article
An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.
Neurobiology of aging - 1 Nov 2020
Roubroeks Janou A Y, Smith Adam R, Smith Rebecca G, Pishva Ehsan, Ibrahim Zina, Sattlecker Martina, Hannon Eilis J, Kłoszewska Iwona, Mecocci Patrizia, Soininen Hilkka, Tsolaki Magda, Vellas Bruno, Wahlund Lars-Olof, Aarsland Dag, Proitsi Petroula, Hodges Angela, Lovestone Simon, Newhouse Stephen J, Dobson Richard J B, Mill Jonathan, van den Hove Daniël L A, Lunnon Katie
Abstract excerpt
A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNeuroMed study, which included 89 nondemented controls, 86 patients with Alzheimer's disease, and 109 individuals with mild...
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