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Article

The Role of Polo-like Kinase 1 in Carcinogenesis: Cause or Consequence?

22 Nov 2013

Abstract excerpt

Polo-like kinase 1 (Plk1) is a well-established mitotic regulator with a diverse range of biologic functions continually being identified throughout the cell cycle. Preclinical evidence suggests that the molecular targeting of Plk1 could be an effective therapeutic strategy in a wide range of cancers; however, that success has yet to be translated to the clinical level. The lack of clinical success has raised the...

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PMID: 24265276
DOI: 10.1158/0008-5472.can-13-2197

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